Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jul-Sep;9(3):233-239.
doi: 10.5005/jp-journals-10005-1370. Epub 2016 Sep 27.

Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review

Harjeet K Sekhon  1 , Keya Sircar  2 , Gurbani Kaur  3 , Muneet Marwah  4
Affiliations
Review

Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review

Harjeet K Sekhon et al. Int J Clin Pediatr Dent. 2016 Jul-Sep.

Abstract

Aim: To conduct a systematic review on the role of myofibroblasts in progression of oral cancer. The myofibroblast is essential for the integrity of the mammalian body by virtue of its role in wound healing, but it also plays a negative role due to their role in promoting tumor development.

Settings and design: Systematic review.

Materials and methods: Bibliographic searches were conducted in several electronic databases using all publications in PubMed, PubMed central, EMBASE, CancerLit, Google scholar, and Cochrane CCTR between 1990 and June 2015.

Results: The search of all publications from various electronic databases revealed 1,371 citations. The total number of studies considered for systematic review was 43. The total number of patients included in the studies was 990.

Conclusion: Myofibroblasts are a significant component in stroma of oral cancer cases, though not identified in all cases. This systematic review shows that clinical, pathological, and immunohistochemistry tests have correlated the presence of high myofibroblast count in oral cancer cell stroma.

Key messages: Myofibroblasts play a significant role in oral cancer invasion and progression. Various studies have demonstrated their association with oral cancer. This review tends to highlight their role in the pathogenesis of oral cancer over the decade.

How to cite this article: Sekhon HK, Sircar K, Kaur G, Marwah M. Evaluation of Role of Myofibroblasts in Oral Cancer: A Systematic Review. Int J Clin Pediatr Dent 2016;9(3):233-239.

Keywords: Myofibroblast; Oral cancer; Precancer..

PubMed Disclaimer

Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Flow Chart 1
Flow Chart 1
Study design
See this image and copyright information in PMC

References

    1. Eyden B. The myofibroblast in health and disease. Rev Esp Patol. 2008;41(1):3–10.
    1. Derek R, Paraic AK, Mina JB. Fibrosis and cancer: myofibroblast come also from epithelial cells via EMT? J Cell Biochem. 2007 Jul 1;101(4):830–839. - PMC - PubMed
    1. Powell WD, Miffin RC, Valentich JD, Crowse SE, Saada JI, West AB. Myofibroblasts: I. Paracrine cells important in health and disease. Am J Physiol. 1999 Jul;277(1 Pt 1):C1–C9. - PubMed
    1. Powell DW. Myofibroblasts: paracrine cells important in health and disease. Trans Am Clin Climatol Assoc. 2000;111:271–292. - PMC - PubMed
    1. Desmouliere A, Darby IA, Gabbiani G. Normal and pathological soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest. 2003 Dec;83(12):1689–1707. - PubMed

LinkOut - more resources