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Case Reports
. 2016 Oct;2(4):212-217.
doi: 10.1159/000444716. Epub 2016 Apr 1.

Neurothekeoma of the Cornea

Mina M Naguib  1 , Caroline Craven  1 , Alan Kozarsky  2 , Hans E Grossniklaus  1
Affiliations
Case Reports

Neurothekeoma of the Cornea

Mina M Naguib et al. Ocul Oncol Pathol. 2016 Oct.

Abstract

Neurothekeomas (NTKs) are benign cutaneous neoplasms of fibrohistiocytic origin and most commonly occur in the head, neck, and upper extremities. Traditionally, NTK and nerve sheath myxoma (NSM) were classified as subtypes of a single neoplasm with a common histogenesis, but recently immunostaining has demonstrated that the lesions are most likely of distinct cellular origin. Rarely, NTKs have been reported to occur in the ocular adnexa, and the present case of a 39-year-old female is the first to describe a cellular NTK originating in the cornea and mimicking a Salzmann's nodular degeneration. This report describes the clinical and pathological findings of the patient, discusses the changes in the classification of these rare neoplasms in light of advances in immunohistochemistry, and reviews all cases of ocular NTK found in the literature.

Keywords: Corneal lesion; Corneal neoplasm; Nerve sheath myxoma; Neurothekeoma.

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Figures

Fig. 1
Fig. 1
a Corneal biopsy showing cellular proliferation in the collagenous matrix. H&E. ×10. b Cellular proliferation consisting of lobules, nests, and sheets of cells surrounded by collagen. H&E. ×25. c Cells containing round to oval vesiculated nuclei, prominent nucleoli, and a moderate amount of eosinophilic cytoplasm. H&E. ×100. Immunohistochemical staining showing weak MITF positivity (d). CD68 positivity (e) and S100 negativity are shown (f). Peroxidase anti-peroxidase technique. ×100.
See this image and copyright information in PMC

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