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. 2016 Oct-Dec;5(4):248-251.
doi: 10.4103/2279-042X.192462.

Addition of cranberry to proton pump inhibitor-based triple therapy for Helicobacter pylori eradication

Mohammadreza Seyyedmajidi  1 , Anahita Ahmadi  1 , Shahin Hajiebrahimi  1 , Seyedali Seyedmajidi  1 , Majid Rajabikashani  1 , Mona Firoozabadi  1 , Jamshid Vafaeimanesh  2
Affiliations

Addition of cranberry to proton pump inhibitor-based triple therapy for Helicobacter pylori eradication

Mohammadreza Seyyedmajidi et al. J Res Pharm Pract. 2016 Oct-Dec.

Abstract

Objective: Proton pump inhibitor-based triple therapy with two antibiotics for Helicobacter pylori eradication is widely accepted, but this combination fails in a considerable number of cases. Some studies have shown that cranberry inhibits the adhesion of a wide range of microbial pathogens, including H. pylori. The aim of this study was to assess the effect of cranberry on H. pylori eradication with a standard therapy including lansoprazole, clarithromycin, and amoxicillin (LCA) in patients with peptic ulcer disease (PUD).

Methods: In this study, H. pylori-positive patients with PUD were randomized into two groups: Group A: A 14-day LCA triple therapy with 30 mg lansoprazole bid, 1000 mg amoxicillin bid, and 500 mg clarithromycin bid; Group B: A 14-day 500 mg cranberry capsules bid plus LCA triple therapy. A 13C-urea breath test was performed for eradication assessment 6 weeks after the completion of the treatment.

Findings: Two hundred patients (53.5% males, between 23 and 77 years, mean age ± standard deviation: 50.29 ± 17.79 years) continued treatment protocols and underwent 13C-urea breath testing. H. pylori eradication was achieved in 74% in Group A (LCA without cranberry) and 89% in Group B (LCA with cranberry) (P = 0.042).

Conclusion: The addition of cranberry to LCA triple therapy for H. pylori has a higher rate of eradication than the standard regimen alone (up to 89% and significant).

Keywords: Cranberry; Helicobacter pylori; eradication therapy.

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Figure 1
Flow diagram of the study
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