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. 2016 Oct-Dec;5(4):257-263.
doi: 10.4103/2279-042X.192461.

A comparison of five common drug-drug interaction software programs regarding accuracy and comprehensiveness

Raziyeh Kheshti  1 , Mohammadsadegh Aalipour  1 , Soha Namazi  1
Affiliations

A comparison of five common drug-drug interaction software programs regarding accuracy and comprehensiveness

Raziyeh Kheshti et al. J Res Pharm Pract. 2016 Oct-Dec.

Abstract

Objective: Drug-drug interactions (DDIs) can cause failure in treatment and adverse events. DDIs screening software is an important tool to aid clinicians in the detection and management of DDIs. However, clinicians should be aware of the advantages and limitations of these programs. We compared the ability of five common DDI programs to detect clinically important DDIs.

Methods: Lexi-Interact, Micromedex Drug Interactions, iFacts, Medscape, and Epocrates were evaluated. The programs' sensitivity, specificity, and positive and negative predictive values were determined to assess their accuracy in detecting DDIs. The accuracy of each program was identified using 360 unknown pair interactions, taken randomly from prescriptions, and forty pairs of clinically important ones. The major reference was a clinical pharmacist alongside the Stockley's Drug Interaction and databases including PubMed, Scopus, and Google Scholar. Comprehensiveness of each program was determined by the number of components in the drug interaction monograph. The aggregate score for accuracy and comprehensiveness was calculated.

Findings: Scoring 250 out of possible 400 points, Lexi-Interact and Epocrates, provided the most accurate software programs. Micromedex, Medscape, and iFacts ranked third, fourth, and fifth, scoring 236, 202, and 191, respectively. In comprehensiveness test, iFacts showed the highest score, 134 out of possible 134 points, whereas Lexi-Interact rated second, with a score of 120. Scoring 370 and 330 out of possible 534 points, Lexi-Interact and Micromedex, respectively, provided the most competent, complete, and user-friendly applications.

Conclusion: Lexi-Interact and Micromedex showed the best performances. An increase in sensitivity is possible by the combination of more than one programs and expert pharmacist intervention.

Keywords: Accuracy; comprehensiveness; drug interaction screening program; drug–drug interactions software.

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References

    1. Bjerrum L, Andersen M, Petersen G, Kragstrup J. Exposure to potential drug interactions in primary health care. Scand J Prim Health Care. 2003;21:153–8. - PubMed
    1. Yeh ML, Chang YJ, Wang PY, Li YC, Hsu CY. Physicians' responses to computerized drug-drug interaction alerts for outpatients. Comput Methods Programs Biomed. 2013;111:17–25. - PubMed
    1. Jankel CA, Fitterman LK. Epidemiology of drug-drug interactions as a cause of hospital admissions. Drug Saf. 1993;9:51–9. - PubMed
    1. Glassman PA, Simon B, Belperio P, Lanto A. Improving recognition of drug interactions: Benefits and barriers to using automated drug alerts. Med Care. 2002;40:1161–71. - PubMed
    1. Weideman RA, Bernstein IH, McKinney WP. Pharmacist recognition of potential drug interactions. Am J Health Syst Pharm. 1999;56:1524–9. - PubMed