doi: 10.1016/0304-3940(89)90045-1.
Sprouting of frog motor nerve terminals after long-term paralysis by botulinum type A toxin
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- PMID: 2784552
- DOI: 10.1016/0304-3940(89)90045-1
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Sprouting of frog motor nerve terminals after long-term paralysis by botulinum type A toxin
Neurosci Lett.
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Abstract
A single sublethal injection of botulinum type A toxin (BoTx-A) to winter frogs induced a general and complete paralysis of skeletal muscles, which lasted several months. Quantitative analysis of 483 end-plates from 8 BoTx-A poisoned muscles and 495 endplates from 8 control muscles revealed a higher and significant incidence of terminal and ultraterminal sprouts in poisoned junctions when taking into account the normal remodelling of motor innervation. We conclude that prolonged neuromuscular blockade by BoTx-A results in the extension of the nerve terminal arborization.
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