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. 1989 Mar;86(6):1963-7.
doi: 10.1073/pnas.86.6.1963.

cDNA sequences of two inducible T-cell genes

B S Kwon  1 , S M Weissman
Affiliations

cDNA sequences of two inducible T-cell genes

B S Kwon et al. Proc Natl Acad Sci U S A. 1989 Mar.

Abstract

We have previously described a set of human T-lymphocyte-specific cDNA clones isolated by a modified differential screening procedure. Apparent full-length cDNAs containing the sequences of 14 of the 16 initial isolates were sequenced and were found to represent five different species of mRNA; three of the five species were identical to previously reported cDNA sequences of preproenkephalin, T-cell-replacing factor, and a serine esterase, respectively. The other two species, 4-1BB and L2G25B, were inducible sequences found in mRNA from both a cytolytic T-lymphocyte and a helper T-lymphocyte clone and were not previously described in T-cell mRNA; these mRNA sequences encode peptides of 256 and 92 amino acids, respectively. Both peptides contain putative leader sequences. The protein encoded by 4-1BB also has a potential membrane anchor segment and other features also seen in known receptor proteins.

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