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. 2017 May 23;8(21):35301-35310.
doi: 10.18632/oncotarget.13312.

Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study

Haidan Lan  1 , Leng Zhou  1 , Dongmei Chi  1 , Qinghua Zhou  2 , XiaoJun Tang  2 , Daxing Zhu  2 , Jianmin Yue  1 , Bin Liu  1
Affiliations

Preoperative platelet to lymphocyte and neutrophil to lymphocyte ratios are independent prognostic factors for patients undergoing lung cancer radical surgery: A single institutional cohort study

Haidan Lan et al. Oncotarget. .

Abstract

Background: The aim of this study was to assess the prognostic value for NSCLC patients who were scheduled to receive lung cancer radical resection.

Methods: In this cohort study (Dec.2014-Feb.2016), patients with non-small cell lung cancer (NSCLC) who underwent radical lung cancer thoracotomy were enrolled and accessed at postoperative complications, one-year overall survival (OS) and relapse-free survival (RFS). The preoperative PLR and NLR of all patients were calculated based on preoperative complete blood counts. Univariate and multivariate Cox regression analyses were performed to determine the associations of PLR and NLR with OS and RFS.

Results: A total of 174 NSCLC patients were studied. The results indicated that both high PLR (>148.6) and NLR (>2.9) were related to a high rate of postoperative pulmonary complications significantly (49.3%vs.29.1%, P = 0.007; 50.7% vs. 28.6%, P = 0.003). Moreover, NSCLC patients with a high PLR level (> 148.6) was significantly associated with a lower one-year OS (90.3% vs. 77.5%, P = 0.034).

Conclusions: Preoperative PLR and NLR were good prognostic factors for postoperative pulmonary complications and OS in NSCLC patients undergoing radical lung cancer surgery. Thus, blood PLR and NLR would be helpful as a prognostic tool before radical lung cancer surgery.

Keywords: neutrophil to lymphocyte ratio; non small cell lung cancer; overall survival; platelet to lymphocyte ratio; postoperative pulmonary complications.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that they have no potential conflict of interest relevant to this article.

Figures

Figure 1
Figure 1. ROC curves for survival predication
ROC curves were potted to verify the accuracy of PLR and NLR for survival. The area under the curve (AUC) was 0.628 (P = 0.037, 0.493-0.763) for PLR, and 0.648(P = 0.016, 0.531-0.766) for NLR.
Figure 2
Figure 2. Kaplan-Meier curves estimates for the effect of pretreatment PLR, PLR on RFS and OS of NSCLC patients
A. Relapse-free survival curves at one year (Kaplan-Meier analysis) for NSCLC patients with PLR≤148.6 or > 148.6. B. Relapse-free survival curves at one year (Kaplan-Meier analysis) for NSCLC patients with NLR≤2.9 or > 2.9. C. Overall survival curves at one year (Kaplan-Meier analysis) for NSCLC patients with PLR≤148.6 or > 148.6. D. Overall survival curves at one year (Kaplan-Meier analysis) for NSCLC patients with NLR≤2.9 or > 2.9. *P < 0.05 is significant
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