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. 2016 Nov 14;30(5):653-654.
doi: 10.1016/j.ccell.2016.10.011.

Cholesterol: An Achilles' Heel for Glioblastoma?

Zhenyi An  1 , William A Weiss  2
Affiliations
Free article

Cholesterol: An Achilles' Heel for Glioblastoma?

Zhenyi An et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Villa et al. report that survival of glioblastoma cells is dependent on uptake of cholesterol. A synthetic agonist of the Liver X receptor depleted cholesterol in GBM cells, slowing growth of GBM xenografts.

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  • An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.
    Villa GR, Hulce JJ, Zanca C, Bi J, Ikegami S, Cahill GL, Gu Y, Lum KM, Masui K, Yang H, Rong X, Hong C, Turner KM, Liu F, Hon GC, Jenkins D, Martini M, Armando AM, Quehenberger O, Cloughesy TF, Furnari FB, Cavenee WK, Tontonoz P, Gahman TC, Shiau AK, Cravatt BF, Mischel PS. Villa GR, et al. Cancer Cell. 2016 Nov 14;30(5):683-693. doi: 10.1016/j.ccell.2016.09.008. Epub 2016 Oct 13. Cancer Cell. 2016. PMID: 27746144 Free PMC article.

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