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Comment
. 2016 Nov 14;30(5):657-658.
doi: 10.1016/j.ccell.2016.10.017.

One Step Forward in the Challenging Arena of MLL-AF4 Leukemia

Nancy J Zeleznik-Le  1
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One Step Forward in the Challenging Arena of MLL-AF4 Leukemia

Nancy J Zeleznik-Le. Cancer Cell. .
Free article

Abstract

MLL-AF4 leukemia is the predominant infant acute leukemia and has a poor prognosis. No current experimental models accurately reflect the human disease. Lin et al., in this issue of Cancer Cell, describe their model that recapitulates multiple key aspects of this aggressive disease, facilitating future mechanistic and preclinical studies.

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