An Alternative Sugar Fuels AML
- PMID: 27846386
- DOI: 10.1016/j.ccell.2016.10.015
An Alternative Sugar Fuels AML
Abstract
Although altered glucose metabolism is a well-studied feature of malignant cells, little is known about the direct metabolism of fructose. In this issue of Cancer Cell, Chen et al. report that AML cells consume fructose and use it to maintain viability, especially when glucose is scarce.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment in
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Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential.Cancer Cell. 2016 Nov 14;30(5):779-791. doi: 10.1016/j.ccell.2016.09.006. Epub 2016 Oct 13. Cancer Cell. 2016. PMID: 27746145 Free PMC article.
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