Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2016 Nov 15;16(1):74.
doi: 10.1186/s12893-016-0191-9.

Exclusive intraoperative radiotherapy for invasive breast cancer in elderly patients (>70 years): proportion of eligible patients and local recurrence-free survival

Eric Lambaudie  1   2   3 , Gilles Houvenaeghel  4   5   6 , Amira Ziouèche  4   5   6 , Sophie Knight  4   5 , François Dravet  7 , Jean Remy Garbay  8 , Sylvie Giard  9 , Hélène Charitansky  10 , Monique Cohen  4   5   6 , Christelle Faure  11 , Delphine Hudry  12 , Paul Azuar  13 , Richard Villet  14 , Pierre Gimbergues  15 , Christine Tunon de Lara  16 , Agnès Tallet  4   5   6 , Marie Bannier  4   5   6 , Mathieu Minsat  4   5   6 , Michel Resbeut  4   5   6
Affiliations
Multicenter Study

Exclusive intraoperative radiotherapy for invasive breast cancer in elderly patients (>70 years): proportion of eligible patients and local recurrence-free survival

Eric Lambaudie et al. BMC Surg. .

Abstract

Background: To estimate the proportion of elderly patients (>70 years) with breast cancer eligible for an Exclusive IntraOperative RadioTherapy (E-IORT) and to evaluate their local recurrence-free survival rate.

Methods: This retrospective study examining two cohorts focuses on patients over 70 years old: a multi-centric cohort of 1411 elderly patients and a mono-centric cohort of 592 elderly patients. All patients underwent conservative surgery followed by external radiotherapy for T0-T3 N0-N1 invasive breast cancer, between 1980 and 2008.

Results: Within each cohort two groups were identified according to the inclusion criteria of the RIOP trial (R group) and TARGIT E study (T group). Each group was divided into two sub-groups, patients eligible (E) or non-eligible (nE) for IORT. The population of patients that were eligible in the TARGIT E study but not in the RIOP trial were also studied in both cohorts. The proportion of patients eligible for IORT was calculated, according to the eligibility criteria of each study. A comparison of the 5-year local or locoregional recurrence-free survival rate between eligible vs non-eligible patients was made. In both cohorts, the proportion of patients eligible according to the RIOP trial's eligibility criteria was 35.4 and 19.3%, and according to the TARGIT E study criteria was 60.9 and 45.3%. The 5-year locoregional recurrence-free survival rate was not significantly different between RE and RnE groups, TE and TnE groups. In both cohorts RE and (TE-RE) groups were not significantly different.

Conclusions: Our results encourage further necessary studies to define and to extend the eligibility criteria for per operative exclusive radiotherapy.

Keywords: Breast cancer; Elderly patients; Intraoperative radiotherapy.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Flowchart figure. Keys: R = RIOP, T = Targit E, E = eligible, nE = not eligible
See this image and copyright information in PMC

References

    1. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) Darby S, McGale P, Correa C, Taylor C, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378:1707–16. doi: 10.1016/S0140-6736(11)60993-8. - DOI - PMC - PubMed
    1. Vaidya JS, Baum M, Tobias JS, Wenz F, Massarut S, et al. Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgery. Int J Radiat Oncol Biol Phys. 2011;346 81(4):1091–7. doi: 10.1016/j.ijrobp.2010.07.1996. - DOI - PubMed
    1. Vaidya JS, Joseph DJ, Tobias JS, Bulsara M, Wenz F, et al. Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet. 2010;376(9735):91–102. doi: 10.1016/S0140-6736(10)60837-9. - DOI - PubMed
    1. Neumaier C, Elena S, Grit W, Yasser AM, Uta KT, et al. TARGIT-E(Elderly)—prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer. BMC Cancer. 2012;12:171. doi: 10.1186/1471-2407-12-171. - DOI - PMC - PubMed
    1. Ziouèche-Mottet A, Houvenaeghel G, Classe JM, Garbay JR, Giard S, et al. Eligibility criteria for intraoperative radiotherapy for breast cancer: study employing 12,025 patients treated in two cohorts. BMC Cancer. 2014;14:868. doi: 10.1186/1471-2407-14-868. - DOI - PMC - PubMed

Publication types

MeSH terms