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Meta-Analysis
. 2016 Nov 15;14(1):315.
doi: 10.1186/s12967-016-1076-5.

Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

Jordano Ferreira Reis  1 , Valter Vinicius Silva Monteiro  1 , Rafaelli de Souza Gomes  2 , Matheus Moraes do Carmo  1 , Glauber Vilhena da Costa  2 , Paula Cardoso Ribera  1 , Marta Chagas Monteiro  3
Affiliations
Meta-Analysis

Action mechanism and cardiovascular effect of anthocyanins: a systematic review of animal and human studies

Jordano Ferreira Reis et al. J Transl Med. .

Abstract

Cardiovascular diseases (CVD) are an important cause of death worldwide. Anthocyanins are a subgroup of flavonoids found in berries, flowers, fruits and leaves. In epidemiological and clinical studies, these polyphenols have been associated with improved cardiovascular risk profiles as well as decreased comorbidities. Human intervention studies using berries, vegetables, parts of plants and cereals (either fresh or as juice) or purified anthocyanin-rich extracts have demonstrated significant improvements in low density lipoproteins oxidation, lipid peroxidation, total plasma antioxidant capacity, and dyslipidemia as well as reduced levels of CVD molecular biomarkers. This review discusses the use of anthocyanins in animal models and their applications in human medicine, as dietary supplements or as new potent drugs against cardiovascular disease.

Keywords: Animal models; Anthocyanins; Cardiovascular disease; Human study; Oxidative stress; Polyphenols.

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Figures

Fig. 1
Fig. 1
Cardiovascular diseases: risk factors and molecular biomarkers. The main risk factors of cardiovascular disease are related to the oxidative stress, generating markers that are used to predict cardiovascular risk
Fig. 2
Fig. 2
Structural body of anthocyanidins. Structural body of anthocyanidins, ion flavilium composed of an aromatic ring (A) condensed with a non-aromatic ring (C) and another aromatic ring (B) forming a carbon–carbon bonding
Fig. 3
Fig. 3
Effects and parameters altered by anthocyanins in humans
See this image and copyright information in PMC

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