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. 2016:2016:3903854.
doi: 10.1155/2016/3903854. Epub 2016 Oct 26.

Thermoregulatory Instability in Childhood: Linking the Normal Brain to Hypothalamic Storm

William Alves Martins  1 , Rafael do Amaral Cristovam  1 , Helena Fussiger  1 , Viviane Maria Vedana  1 , Marta Hemb  2
Affiliations

Thermoregulatory Instability in Childhood: Linking the Normal Brain to Hypothalamic Storm

William Alves Martins et al. Case Rep Neurol Med. 2016.

Abstract

Central core temperature is tightly controlled by hypothalamic centers, a feature that makes sudden changes in body temperature very unusual. A dysfunction of these hypothalamic pathways leads to Shapiro's syndrome, comprising spontaneous hypothermia, hyperhidrosis, and corpus callosum dysgenesis. Although it may affect any age, usually it presents in childhood. Variants to this syndrome with completely normal brain anatomy have been consistently reported, expanding the clinical spectrum of the syndrome. Herein, we report the case of a 4-year-old girl with Shapiro's syndrome and unaffected corpus callosum.

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Figures

Figure 1
Figure 1
Brain MRI. Sagittal T1-weighted image demonstrating intact corpus callosum.
See this image and copyright information in PMC

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