BTLA⁺ Dendritic Cells: The Regulatory T Cell Force Awakens

Thomas Simon¹, Jonathan S Bromberg²

Affiliations

¹ Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, Baltimore, MD 21201, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.
² Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, Baltimore, MD 21201, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA. Electronic address: jbromberg@smail.umaryland.edu.

PMID: 27851922
DOI: 10.1016/j.immuni.2016.10.030

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BTLA⁺ Dendritic Cells: The Regulatory T Cell Force Awakens

Thomas Simon et al. Immunity. 2016.

Free article

. 2016 Nov 15;45(5):956-958.

doi: 10.1016/j.immuni.2016.10.030.

Authors

Thomas Simon¹, Jonathan S Bromberg²

Affiliations

¹ Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, Baltimore, MD 21201, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA.
² Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, Baltimore, MD 21201, USA; Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, 800 West Baltimore Street, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, 22 South Greene Street, Baltimore, MD 21201, USA. Electronic address: jbromberg@smail.umaryland.edu.

PMID: 27851922
DOI: 10.1016/j.immuni.2016.10.030

Abstract

The role of dendritic cells (DCs) in the induction of antigen-specific tolerance mediated by extrathymic regulatory T (Treg) cells remains incompletely defined. In this issue of Immunity, Jones et al. (2016) show that BTLA⁺DEC205⁺CD8⁺CD11c⁺ DCs efficiently induce peripheral Treg cells via the engagement of HVEM, a receptor for BTLA.

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Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.
Jones A, Bourque J, Kuehm L, Opejin A, Teague RM, Gross C, Hawiger D. Jones A, et al. Immunity. 2016 Nov 15;45(5):1066-1077. doi: 10.1016/j.immuni.2016.10.008. Epub 2016 Oct 25. Immunity. 2016. PMID: 27793593 Free PMC article.

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BTLA⁺ Dendritic Cells: The Regulatory T Cell Force Awakens

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BTLA⁺ Dendritic Cells: The Regulatory T Cell Force Awakens

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