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Review
. 2017 Feb 14;8(7):12389-12405.
doi: 10.18632/oncotarget.13310.

Bevacizumab in ovarian cancer: A critical review of phase III studies

Luigi Rossi  1 , Monica Verrico  1 , Eleonora Zaccarelli  1 , Anselmo Papa  1 , Maria Colonna  2 , Martina Strudel  1 , Patrizia Vici  3 , Vincenzo Bianco  4 , Federica Tomao  5
Affiliations
Review

Bevacizumab in ovarian cancer: A critical review of phase III studies

Luigi Rossi et al. Oncotarget. .

Abstract

Bevacizumab (BV) is a humanized monoclonal antibody targeting vascular endothelial growth factor and it is the first molecular-targeted agent to be used for the treatment of ovarian cancer (OC). Randomized Phase III trials evaluated the combination of BV plus standard chemotherapy for first-line treatment of advanced OC and for platinum-sensitive and platinum-resistant recurrent OC. These trials reported a statistically significant improvement in progression-free survival but not in overall survival. Furthermore, BV effectively improved the quality of life with regard to abdominal symptoms in recurrent OC patients. Bevacizumab is associated with adverse events such as hypertension, bleeding, thromboembolism, proteinuria, delayed wound healing, and gastrointestinal events. However, most of these events can be adequately managed. This review describes the latest evidence for BV treatment of OC and selection of patients for personalized treatment.

Keywords: anti-angiogenic therapy; bevacizumab; biological therapy; chemotherapy; ovarian cancer.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents, received or pending, or royalties.

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