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Review
. 2016 Sep;64(9):628-634.
doi: 10.4103/0301-4738.194339.

Roles of interleukin-17 in uveitis

Marta Catarina Esteves Guedes  1 , Luis Miguel Borrego  2 , Rui Daniel Proença  3
Affiliations
Review

Roles of interleukin-17 in uveitis

Marta Catarina Esteves Guedes et al. Indian J Ophthalmol. 2016 Sep.

Abstract

Th17 cells, a CD4+ T-cell subset, produce interleukin (IL)-17, a pro-inflammatory cytokine that has been shown to be involved in several forms of infectious and noninfectious uveitis. Here, we explore the roles of this IL in uveitic disorders as well as in experimental autoimmune uveitis, the possible pathogenic implications of several cytokines associated with IL-17 and analyze the current outcomes and goals for drugs aiming for the IL-17 pathway.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Both interleukin-6 and interleukin-21 can cooperate with transforming growth factor-β to promote Th17 differentiation from CD4+ Th-cells while interleukin-23 is important for Th17 cell expansion and activation. Interferon-γ and interleukin-27 have regulatory roles through the suppression of Th17 differentiation. Note that the sole presence of transforming growth factor-β induces Treg cell production from CD4+ Th-cells
See this image and copyright information in PMC

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