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Case Reports
. 2016;55(22):3341-3345.
doi: 10.2169/internalmedicine.55.7226. Epub 2016 Nov 15.

Acute Promyelocytic Leukemia with i(17)(q10)

Junki Inamura  1 , Katsuya Ikuta, Nodoka Tsukada, Takaaki Hosoki, Motohiro Shindo, Kazuya Sato
Affiliations
Case Reports

Acute Promyelocytic Leukemia with i(17)(q10)

Junki Inamura et al. Intern Med. 2016.

Abstract

We herein report a rare chromosomal abnormality observed in an acute promyelocytic leukemia (APL) patient. She had several APL derivative clones including a clone with i(17)(q10) abnormality, which consists of two kinds of structural abnormalities, a cryptic translocation of t(15;17) and an isochromosome of 17q. Although an obvious microscopic t(15;17) change was not observed on either arms of the isochromosome, PML/RARα fusion signals were detected on an interphase fluorescence in situ hybridization analysis. By several cytogenetic analyses of her bone marrow cells, it was confirmed that the i(17)(q10) clone was derived from the classic t(15;17) clone via another intervening clone, cryptic t(15;17).

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Figures

Figure 1.
Figure 1.
A G-banding chromosomal analysis at the diagnosis. An isochromosome of 17q was detected, although there was no evidence of microscopic t(15;17) changes on either chromosome 15 or the isochromosome. The karyotype was described as 46,XX,i(17)(q10).
Figure 2.
Figure 2.
Hypothesis of the i(17)(q10) clone derivation process. “Clone A” is the classic APL clone with t(15;17). “Clone B” is the so-called cryptic t(15;17) clone, which is derived from Clone A via re-translocation, and minute fragments are left on both chromosomes 15 and 17 reciprocally. “Clone C” is derived from Clone B via an isochromosome change on 17q. Both the normal clone and Clone B show a normal karyotype on chromosomal analyses. Both Clone A and Clone B show the same signal pattern, yellow:red:green=2:1:1, on interphase FISH analyses. Clone C shows i(17)(q10) with no evidence of translocation on a chromosomal analysis and shows yellow:red:green=3:1:1 signals on an interphase FISH analysis.
See this image and copyright information in PMC

References

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