Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Feb;37(2):157-161.
doi: 10.1038/jp.2016.201. Epub 2016 Nov 17.

Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing

V Parente  1 , R H Clark  2 , L Ku  1 , C Fennell  3 , M Johnson  3 , E Morris  3 , A Romaine  3 , U Utin  3 , D K Benjamin  1   3 , J A Messina  3 , P B Smith  1   3 , R G Greenberg  1   3
Affiliations

Risk factors for group B streptococcal disease in neonates of mothers with negative antenatal testing

V Parente et al. J Perinatol. 2017 Feb.

Abstract

Objective: The aim of this study was to identify risk factors for early-onset group B Streptococcus (EOGBS) disease in neonates of mothers with negative antenatal screening.

Study design: We performed a retrospective cohort study of neonates born to mothers with negative antenatal GBS screening between 2002 and 2012. Our primary outcome was EOGBS infection. We used multivariable logistic regression to assess factors associated with EOGBS.

Results: EOGBS was confirmed in 492 of the 179 818 neonates that met the study inclusion criteria. Risk factors for EOGBS included black race (reference: white, odds ratio (OR) =1.81 (95% confidence interval: 1.43, 2.31)), maternal age <18 years (reference: >35 years, OR=2.63 (1.54, 4.51)) and maternal age 18 to 35 years (reference: >35 years, OR=1.94 (1.30, 2.88)).

Conclusion: Maternal age <18 years and black race were the strongest predictors of EOGBS. Further research investigating contributors to the discordance between screening results and neonatal outcomes in these populations is needed.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Study Population
See this image and copyright information in PMC

References

    1. Van Dyke MK, Phares CR, Lynfield R, Thomas AR, Arnold KE, Craig AS, et al. Evaluation of universal antenatal screening for group B streptococcus. N Engl J Med. 2009 Jun 18;360(25):2626–2636. - PubMed
    1. Trends in perinatal group B streptococcal disease - United States, 2000–2006. MMWR Morb Mortal Wkly Rep. 2009 Feb 13;58(5):109–112. - PubMed
    1. Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005. JAMA. 2008 May 7;299(17):2056–2065. - PubMed
    1. Stoll BJ, Hansen NI, Sanchez PJ, Faix RG, Poindexter BB, Van Meurs KP, et al. Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues. Pediatrics. 2011 May;127(5):817–826. - PMC - PubMed
    1. Heath PT, Balfour G, Weisner AM, Efstratiou A, Lamagni TL, Tighe H, et al. Group B streptococcal disease in UK and Irish infants younger than 90 days. Lancet. 2004 Jan 24;363(9405):292–294. - PubMed

MeSH terms