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Review
. 2016 Nov 7:10:149-156.
doi: 10.2147/BTT.S87385. eCollection 2016.

Update on sepsis-associated acute kidney injury: emerging targeted therapies

James F Doyle  1 , Lui G Forni  2
Affiliations
Review

Update on sepsis-associated acute kidney injury: emerging targeted therapies

James F Doyle et al. Biologics. .

Abstract

Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased mortality and morbidity. It is essential that further advances in the treatment of sepsis should prioritize targeted therapies in SA-AKI in order to improve these bleak outcomes. As yet, a unique therapy that effectively reduces the impact of acute kidney injury has not been demonstrated. However, the emergence of novel targeted therapies, perhaps in combination, has the possibility of significantly reducing the long-term sequelae of an episode of SA-AKI. In this review, we will focus on the shared etiology of these conditions and how this is managed with targeted therapy and finally the emerging novel therapies that may play an additional role to current treatment strategies.

Keywords: acute kidney injury; novel targeted therapy outcome; sepsis.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Pathophysiology of sepsis associated acute kidney injury. Note: Data from Prowle and Bellomo. Abbreviations: GFR, glomerular filtration rate; RBF, renal blood flow; SA-AKI, sepsis-associated acute kidney injury.
See this image and copyright information in PMC

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