Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Nov 7:10:149-156.
doi: 10.2147/BTT.S87385. eCollection 2016.

Update on sepsis-associated acute kidney injury: emerging targeted therapies

James F Doyle  1 , Lui G Forni  2
Affiliations
Review

Update on sepsis-associated acute kidney injury: emerging targeted therapies

James F Doyle et al. Biologics. .

Abstract

Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased mortality and morbidity. It is essential that further advances in the treatment of sepsis should prioritize targeted therapies in SA-AKI in order to improve these bleak outcomes. As yet, a unique therapy that effectively reduces the impact of acute kidney injury has not been demonstrated. However, the emergence of novel targeted therapies, perhaps in combination, has the possibility of significantly reducing the long-term sequelae of an episode of SA-AKI. In this review, we will focus on the shared etiology of these conditions and how this is managed with targeted therapy and finally the emerging novel therapies that may play an additional role to current treatment strategies.

Keywords: acute kidney injury; novel targeted therapy outcome; sepsis.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Pathophysiology of sepsis associated acute kidney injury. Note: Data from Prowle and Bellomo. Abbreviations: GFR, glomerular filtration rate; RBF, renal blood flow; SA-AKI, sepsis-associated acute kidney injury.
See this image and copyright information in PMC

References

    1. Barbar SD, Binquet C, Monchi M, Bruyère R, Quenot JP. Impact on mortality of the timing of renal replacement therapy in patients with severe acute kidney injury in septic shock: the IDEAL-ICU study (initiation of dialysis early versus delayed in the intensive care unit): study protocol for a randomized controlled trial. Trials. 2014;15:270. - PMC - PubMed
    1. Mickells GE, Moge MA, Smith CM. Acute kidney injury in pediatric sepsis. Clin pediatr Emerg Med. 2014;15(2):185–192.
    1. Bagshaw SM, George C, Bellomo R, Committee ADM. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care. 2008;12(2):R47. - PMC - PubMed
    1. Oppert M, Engel C, Brunkhorst FM, et al. Acute renal failure in patients with severe sepsis and septic shock – a significant independent risk factor for mortality: results from the German Prevalence Study. Nephrol Dial Transplant. 2008;23(3):904–909. - PubMed
    1. Prowle JR, Bellomo R. Sepsis-associated acute kidney injury: macrohemodynamic and microhemodynamic alterations in the renal circulation. Semin Nephrol. 2015;35(1):64–74. - PubMed