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Review
. 2016;36(5):605-624.
doi: 10.1007/s40846-016-0164-6. Epub 2016 Oct 11.

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Souvik Das  1 , Saurabh Pal  2 , Madhuchhanda Mitra  2
Affiliations
Review

Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus

Souvik Das et al. J Med Biol Eng. 2016.

Abstract

Analysis of volatile organic compounds (VOCs) emanating from human exhaled breath can provide deep insight into the status of various biochemical processes in the human body. VOCs can serve as potential biomarkers of physiological and pathophysiological conditions related to several diseases. Breath VOC analysis, a noninvasive and quick biomonitoring approach, also has potential for the early detection and progress monitoring of several diseases. This paper gives an overview of the major VOCs present in human exhaled breath, possible biochemical pathways of breath VOC generation, diagnostic importance of their analysis, and analytical techniques used in the breath test. Breath analysis relating to diabetes mellitus and its characteristic breath biomarkers is focused on. Finally, some challenges and limitations of the breath test are discussed.

Keywords: Breath analysis; Breath biomarkers; Diabetes mellitus; Disease diagnosis; Noninvasive method; Volatile organic compound.

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Figures

Fig. 1
Fig. 1
Generation pathway of acetone in liver by hepatocytes [2]
Fig. 2
Fig. 2
Possible reactions and their products in free-radical-mediated lipid peroxidation [2]
Fig. 3
Fig. 3
Metabolic pathway of cholesterol synthesis and isoprene generation [61]
See this image and copyright information in PMC

References

    1. Francesco FD, Fuoco R, Trivella MG, Ceccarini A. Breath analysis: Trends in techniques and clinical applications. Microchemical Journal. 2005;79:405–410. doi: 10.1016/j.microc.2004.10.008. - DOI
    1. Miekisch W, Schubert JK, Noeldge-Schomburg GFE. Diagnostic potential of breath analysis—Focus on volatile organic compounds. Clinica Chimica Acta. 2004;347:25–39. doi: 10.1016/j.cccn.2004.04.023. - DOI - PubMed
    1. Dent AG, Sutedja TG, Zimmerman PV. Exhaled breath analysis for lung cancer. Journal of Thoracic Disease. 2013 - PMC - PubMed
    1. Kim KH, Jahan SA, Kabir E. A review of breath analysis for diagnosis of human health. Trends in Analytical Chemistry. 2012;33:1–8. doi: 10.1016/j.trac.2011.09.013. - DOI
    1. Righettoni M, Amann A, Pratsinis SE. Breath analysis by nanostructured metal oxides as chemo-resistive gas sensors. Materials Today. 2015;18(3):163–171. doi: 10.1016/j.mattod.2014.08.017. - DOI