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. 2016 Sep;5(3):259-264.

The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice

Mohaddese Mahboubi  1 , Mohammad Mehdi Feizabadi  2 , Tahereh Khamechian  3 , Nastaran Kazempour  1 , Mohsen Razavi Zadeh  4 , Farhang Sasani  5 , Mohsen Bekhradi  6
Affiliations

The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice

Mohaddese Mahboubi et al. World J Plast Surg. 2016 Sep.

Abstract

Background: Staphylococcus aureus is one of the most causative organisms in the skin wound infections. Development of resistant S. aureus to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection.

Methods: The efficacy of herbal formulation containing Oliveria decumbens and Pelargonium graveolens essential oils was evaluated in comparison to mupirocin against Methicillin Resistant S. aureus (MRSA) related skin wound infection in mice animal model.

Results: The herbal cream and mupirocin decreased the log CFU by 2.5±0.26 and 2.46±0.32, respectively, while the log CFU of S. aureus from wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction.

Conclusion: This natural new formulation with O. decumbens and P. graveolens essential oils could be recommended as a new candidate for wound healing.

Keywords: Healing; Infected wound; Mouse; Oliveria decumbens; Pelargonium graveolens.

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Figures

Fig. 1
Fig. 1
Microscopic evaluation of Hematoxylin & Eosin stained sections (Ma ×40). A) Control, B) Herbal cream, C) Mupirocin, D) Placebo (Control).
See this image and copyright information in PMC

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