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Meta-Analysis
. 2016 Nov 16;13(11):1139.
doi: 10.3390/ijerph13111139.

The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

Jin Yan  1   2 , Qiang She  3   4 , Yifeng Zhang  5   6 , Chang Cui  7   8 , Guoxin Zhang  9   10
Affiliations
Meta-Analysis

The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

Jin Yan et al. Int J Environ Res Public Health. .

Abstract

Arrhythmia is a common disease around the world and Helicobacter pylori (H. pylori) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori. We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori. In the arrhythmia group, 392 (58.1%) were H. pylori-positive and in the control group 640 (47.8%) were H. pylori-positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081-2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may exist and H. pylori eradication may decrease the occurrence of arrhythmia, especially in Asia and Africa.

Keywords: Helicobacter pylori; arrhythmia; meta-analysis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study selection process.
Figure 2
Figure 2
Effect estimates and pooled estimate of included studies reporting the association of arrhythmia and Helicobacter pylori infection. OR, odds ratio; CI, confidence interval.
Figure 3
Figure 3
Forest plot showing the relationship between arrhythmia and Helicobacter pylori infection: studies divided into subgroups according to the type of arrhythmia. OR, odds ratio; CI, confidence interval.
Figure 4
Figure 4
Forest plot showing the relationship between arrhythmia and Helicobacter pylori infection: studies divided into subgroups according to the continent of study origin. OR, odds ratio; CI, confidence interval.
Figure 5
Figure 5
Sensitivity analysis of the meta-analysis.
Figure 6
Figure 6
Funnel plot to explore publication bias.
See this image and copyright information in PMC

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