Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 May;108(5):1935-43.
doi: 10.1083/jcb.108.5.1935.

A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis

H D Gresham  1 , J L Goodwin, P M Allen, D C Anderson, E J Brown
Affiliations

A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis

H D Gresham et al. J Cell Biol. 1989 May.

Abstract

Human neutrophils (PMN) express a heterodimeric receptor that has ligand binding specificity for the Arg-Gly-Asp (RGD) sequence within many adhesive proteins. A monoclonal antibody, B6H12, which binds to this receptor, inhibits both RGD-mediated ligand binding and stimulation of IgG-mediated phagocytosis by fibronectin, fibrinogen, vitronectin, von Willebrand's factor, and collagen type IV. By several criteria this receptor is neither a known very late antigen, a known cytoadhesin (gp IIb/IIIa-vitronectin receptor), nor a member of the LFA-1, Mac-1, p150,95 group of integrin receptors. Ligand binding via this receptor is rapidly inactivated by products of the myeloperoxidase-hydrogen peroxide-halide system of PMN. We conclude that this receptor, for which we propose the name leukocyte response integrin, is a signal-transducing molecule on PMN which may have a significant early role in modulation of PMN function at inflammatory sites.

PubMed Disclaimer

References

    1. Scand J Clin Lab Invest Suppl. 1968;97:77-89 - PubMed
    1. J Cell Biol. 1988 Nov;107(5):1893-900 - PubMed
    1. J Exp Med. 1983 Jun 1;157(6):1844-54 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5699-703 - PubMed
    1. J Exp Med. 1984 Jan 1;159(1):137-51 - PubMed

Publication types