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Randomized Controlled Trial
. 2016 Nov 17;16(1):115.
doi: 10.1186/s12871-016-0279-x.

Comparison of hemodynamic response to tracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture under general anesthesia: a randomized controlled trial comparing fentanyl and oxycodone

Yeon Sil Lee  1 , Chong Wha Baek  2 , Dong Rim Kim  1 , Hyun Kang  1 , Geun Joo Choi  1 , Yong-Hee Park  1 , Won-Joong Kim  1 , Yong Hun Jung  1 , Young Cheol Woo  1
Affiliations
Randomized Controlled Trial

Comparison of hemodynamic response to tracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture under general anesthesia: a randomized controlled trial comparing fentanyl and oxycodone

Yeon Sil Lee et al. BMC Anesthesiol. .

Abstract

Background: The present study aimed to compare the intravenous bolus effect of oxycodone and fentanyl on hemodynamic response after endotracheal intubation and postoperative pain in patients undergoing closed reduction of nasal bone fracture.

Methods: In this prospective randomized double-blinded study, 64 patients undergoing closed reduction of nasal bone fracture were randomized into one of two groups: the fentanyl group (Group F) or the oxycodone group (Group O). Each drug (fentanyl 2 mcg/kg in Group F and oxycodone 0.2 mg/kg in Group O) was administered prior to the induction of general anesthesia. Hemodynamic changes after endotracheal intubation and postoperative pain were then measured in both groups.

Results: There was no significant difference in the change in mean arterial pressure and heart rate between pre-induction and post-intubation in both Groups F and O (P > 0.05). Postoperative pain in Group O was milder than that in Group F (P < 0.001); however, time to awakening from the end of operation was shorter in Group F (P = 0.012).

Conclusion: In patients undergoing closed reduction of nasal bone fracture, oxycodone attenuates hemodynamic response to endotracheal intubation similar to fentanyl. However, oxycodone is more effective than fentanyl in improving postoperative pain.

Trial registration: Clinical Research Information Service (Trial registry number: KCT0001153 ) on 3 July, 2014.

Keywords: Fentanyl; Hemodynamics; Intubation; Oxycodone; Postoperative pain.

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Figures

Fig. 1
Fig. 1
CONSORT flowchart showing the number of patients at each study phase
See this image and copyright information in PMC

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