The use of bioceramics in endodontics - literature review
- PMID: 27857514
- PMCID: PMC5111485
- DOI: 10.15386/cjmed-612
The use of bioceramics in endodontics - literature review
Abstract
Background and aim: Bioceramics are ceramic compounds obtained both in situ and in vivo, by various chemical processes. Bioceramics exhibit excellent biocompatibility due to their similarity with biological materials, like hydroxyapatite. Bioceramics and multi-substituted hydroxyapatite or similar compounds have the ability to induce a regenerative response in the organism. The aim of this paper is to make a literature review on the main bioceramic materials currently used in endodontics and on their specific characteristics.
Methods: We conducted a search in the international databases (PubMed), to identify publications in the last 10 years, using the following key words: "bioceramics endodontics", "bioceramic endodontic cement", "bioceramic sealer" and "direct pulp capping bioceramic".
Results: Commonly used endodontic sealers (e.g., containing zinc oxide, calcium hydroxide and a resin) have a long tradition in scientific research and clinical use in endodontics. For specific cases, like root resorptions, perforations, apexification, and retrograde fillings, new biocompatible materials were developed in order to improve the clinical outcome: ProRooT MTA (Dentsply Company, Germany); Biodentine (Septodont, France); Endosequence BC sealer (Brassler, SUA); Bioaggregate (IBC, Canada); Generex A (Dentsply Tulsa Dental Specialties, USA).
Conclusion: The studies are generally in favor of bioceramic materials even if there are not many products available on the market for endodontic use. As more products are launched and more research is performed regarding these materials, we will provide more reliable data on clinical outcome.
Keywords: bioceramics; biodentine; endodontics.
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References
-
- Cheng L, Ye F, Yang R, Lu X, Shi Y, Li L, et al. Osteoinduction of hydroxyapatite/beta-tricalcium phosphate bioceramics in mice with a fractured fibula. Acta Biomater. 2010;6(4):1569–1574. - PubMed
-
- Hermansson L. Nanostructural bioceramics: Advances in Chemically Bonded Bioceramics. CRC Press; 2014.
-
- Tomoaia G, Tomoaia-Cotisel M, Pop LB, Mocanu A, Pop A. Nanopowders of hydroxyapatite and its substituted derivatives with medical applications and their fabrication procedure. A20100523. Romanian Patent. 2013 Apr 10;
-
- Estrela C, Bammann LL, Estrela CR, Silva RS, Pécora JD. Antimicrobial and chemical study of MTA, Portland cement, calcium hydroxide paste, Sealapex and Dycal. Braz Dent J. 2000;11:3–9. - PubMed
-
- Funteas UR, Wallace JA, Fochtman EW. A comparative analysis of Mineral Trioxide Aggregate and Portland cement. Aust Endod J. 2003;29:43–44. - PubMed
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