[Clinical effect of Nd:YAG laser combined with total glucosides of paeony for the treatment of erosive oral lichen planus]
- PMID: 27858075
[Clinical effect of Nd:YAG laser combined with total glucosides of paeony for the treatment of erosive oral lichen planus]
Abstract
Purpose: To investigate the clinical effect of Nd:YAG laser combined with total glucosides of paeony (TGP) taken orally for the treatment of erosive oral lichen planus (OLP).
Methods: Sixty patients who were diagnosed as erosive OLP with clinical symptoms were divided into experimental group (n=28) and control group (n=32) using a random number table. All patients received TGP while the patients in the experimental group were given Nd:YAG laser irradiation. The clinical effects were evaluated 3 months after treatment. The data were analyzed using SPSS 17.0 software package.
Results: Three months later, the average VAS score and sign score had improved significantly to (1.36±1.39) and (2.32±1.56) in the experimental group. The same tendency was observed in the control group and at the time point no significant difference was observed between the experimental group and the control group. The effectiveness of the experimental group was significantly higher than the control group (82.1% vs 53.1%).
Conclusions: Nd: YAG laser combined with TGP can improve the efficacy of erosive OLP. The regime is safe and effective, which is worth of wide clinical application.
Similar articles
-
Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids.Int Immunopharmacol. 2016 Jul;36:106-110. doi: 10.1016/j.intimp.2016.03.035. Epub 2016 Apr 26. Int Immunopharmacol. 2016. PMID: 27129091 Clinical Trial.
-
Comparison of the effect of the pulsed Er: YAG laser and topical corticosteroid on erosive oral lichen planus: a randomized clinical controlled trial.Lasers Med Sci. 2025 Apr 8;40(1):180. doi: 10.1007/s10103-025-04419-6. Lasers Med Sci. 2025. PMID: 40198390 Free PMC article. Clinical Trial.
-
Total glucosides of paeony (TGP) inhibits the production of inflammatory cytokines in oral lichen planus by suppressing the NF-κB signaling pathway.Int Immunopharmacol. 2016 Jul;36:67-72. doi: 10.1016/j.intimp.2016.04.010. Epub 2016 Apr 22. Int Immunopharmacol. 2016. PMID: 27107800
-
Phototherapy approaches in treatment of oral lichen planus.Photodermatol Photoimmunol Photomed. 2014 Feb;30(1):15-24. doi: 10.1111/phpp.12074. Epub 2013 Oct 11. Photodermatol Photoimmunol Photomed. 2014. PMID: 24118508 Review.
-
[The research progress of CO(2) laser in the treatment of oral lichen planus].Zhonghua Kou Qiang Yi Xue Za Zhi. 2017 Jun 9;52(6):390-392. doi: 10.3760/cma.j.issn.1002-0098.2017.06.015. Zhonghua Kou Qiang Yi Xue Za Zhi. 2017. PMID: 28613065 Review. Chinese.
Cited by
-
Efficacy of low-level laser therapy in management of symptomatic oral lichen planus: a systematic review.Lasers Med Sci. 2017 Aug;32(6):1429-1437. doi: 10.1007/s10103-017-2233-7. Epub 2017 May 24. Lasers Med Sci. 2017. PMID: 28536905
-
Acute Toxicity of Dental Gel Based on Origanum vulgare in Mice.J Toxicol. 2023 Sep 14;2023:6691694. doi: 10.1155/2023/6691694. eCollection 2023. J Toxicol. 2023. PMID: 37746316 Free PMC article.
-
Integrative Approaches for the Diagnosis and Management of Erosive Oral Lichen Planus.Diagnostics (Basel). 2024 Mar 26;14(7):692. doi: 10.3390/diagnostics14070692. Diagnostics (Basel). 2024. PMID: 38611605 Free PMC article. Review.