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Comparative Study
. 2017 Apr;40(4):431-435.
doi: 10.1007/s40618-016-0585-7. Epub 2016 Nov 17.

Thiol/disulfide homeostasis in postmenopausal osteoporosis

V Korkmaz  1 , Z Kurdoglu  2 , M Alisik  3 , E Turgut  2 , O O Sezgın  4 , H Korkmaz  5 , Y Ergun  2 , O Erel  3
Affiliations
Comparative Study

Thiol/disulfide homeostasis in postmenopausal osteoporosis

V Korkmaz et al. J Endocrinol Invest. 2017 Apr.

Abstract

Aim: To evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis.

Materials and methods: A total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups.

Results: The disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05).

Conclusion: Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.

Keywords: Disulfide; Postmenopausal osteoporosis; Thiol.

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