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. 1989 Apr;8(3):171-7.
doi: 10.1089/dna.1.1989.8.171.

Identification of serum-responsive elements in the promoter of human calcyclin, a growth-regulated gene

F Ghezzo  1 , S Valpreda, J K De Riel, R Baserga
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Identification of serum-responsive elements in the promoter of human calcyclin, a growth-regulated gene

F Ghezzo et al. DNA. 1989 Apr.

Abstract

The calcyclin gene is growth regulated in a number of cell types from different animal species. We have identified in the promoter region of the human calcyclin gene the sequences responsible for its growth regulation by serum. A number of deletion mutants and synthetic nucleotides, all driving the chloroamphenicol transferase (CAT) gene, were constructed for this purpose. Serum-responsive elements can be localized in the last 42 bp immediately upstream from the CAP site.

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