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Review
. 2017 Mar;65(3):1039-1043.
doi: 10.1002/hep.28948. Epub 2017 Jan 11.

The origin of fibrogenic myofibroblasts in fibrotic liver

Tatiana Kisseleva  1
Affiliations
Review

The origin of fibrogenic myofibroblasts in fibrotic liver

Tatiana Kisseleva. Hepatology. 2017 Mar.

Abstract

Liver fibrosis results from chronic liver injury of different etiologies. It is characterized by dysregulation of physiological remodeling, activation of myofibroblasts, and formation of a fibrous scar. Myofibroblasts develop contractile functions and secrete the extracellular matrix proteins that form this fibrous scar. Myofibroblasts are not present in the normal liver but activate and proliferate in response to injury and inflammation. This review summarizes the understanding and controversies on the contribution of cell populations to the myofibroblasts in liver fibrosis. (Hepatology 2017;65:1039-1043).

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Conflict of interest statement

Potential conflict of interest: Nothing to report.

Figures

FIG. 1
FIG. 1
Specific markers of activated HSCs, quiescent HSCs, and inactivated HSCs, activated PFs, fibrocytes, and mesothelial cells (explanations are in the text). Abbreviations: aHSC, activated HSC; aSMA, alpha–smooth muscle actin; CCR, chemokine (C-C motif) receptor; CD, cluster of differentiation; Col1a1, collagen type 1a1; GFAP, glial fibrillary acidic protein; iHSC, inactivated HSC; MHC-II, major histocompatibility complex II; PPAR, peroxisome proliferator–activated receptor; qHSC, quiescent HSC.
See this image and copyright information in PMC

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