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Clinical Trial
. 2017 Jun;64(6):10.1002/pbc.26338.
doi: 10.1002/pbc.26338. Epub 2016 Nov 15.

Late outcomes of adult survivors of childhood non-Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study

Matthew J Ehrhardt  1   2 , John T Sandlund  1 , Nan Zhang  3   4 , Wei Liu  3 , Kirsten K Ness  2 , Nickhill Bhakta  1 , Wassim Chemaitilly  1   5 , Kevin R Krull  2   6 , Tara M Brinkman  2   6 , Deborah B Crom  1 , Larry Kun  7 , Sue C Kaste  7 , Gregory T Armstrong  1   2 , Daniel M Green  1   2 , Kumar Srivastava  3 , Leslie L Robison  2 , Melissa M Hudson  1   2 , Daniel A Mulrooney  1   2
Affiliations
Clinical Trial

Late outcomes of adult survivors of childhood non-Hodgkin lymphoma: A report from the St. Jude Lifetime Cohort Study

Matthew J Ehrhardt et al. Pediatr Blood Cancer. 2017 Jun.

Abstract

Background: Survivors of childhood non-Hodgkin lymphoma (NHL) are at increased risk for chronic health conditions. The objective of this study was to characterize health conditions, neurocognitive function, and physical performance among a clinically evaluated cohort of 200 childhood NHL survivors.

Method: Chronic health and neurocognitive conditions were graded as per a modified version of the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) and impaired physical function defined as performance < 10th percentile of normative data. Multivariable regression was used to investigate associations between sociodemographic characteristics, therapeutic exposures, and outcomes.

Results: Survivors were a median age of 10 years (range 1-19) at diagnosis and 34 years (range 20-58) at evaluation. Eighty-eight (44%) received radiation, 46 (23%) cranial radiation, and 69 (35%) high-dose methotrexate. Most prevalent CTCAE Grades 3-4 (severe life-threatening) conditions were obesity (35%), hypertension (9%), and impairment of executive function (13%), attention (9%), and memory (4%). Many had impaired strength (48%), flexibility (39%), muscular endurance (36%), and mobility (36%). Demographic and treatment-related factors were associated with the development of individual chronic diseases and functional deficits.

Conclusions: Clinical evaluation identified a high prevalence of chronic health conditions, neurocognitive deficits, and performance limitations in childhood NHL survivors.

Keywords: chronic health conditions; late effects; neurocognitive; non-Hodgkin lymphoma; survivorship.

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Conflict of interest statement

CONFLICT OF INTEREST STATMENT

The author(s) indicated no potential conflicts of interest.

Figures

Figure 1
Figure 1
Neurocognitive impairment among adult survivors of NHL
Figure 2
Figure 2
Physical performance deficits among adult survivors of NHL
See this image and copyright information in PMC

References

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