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. 2017 Apr;35(4):1015-1027.
doi: 10.1002/stem.2540. Epub 2016 Nov 23.

Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle

Vanessa Besson  1 , Sergiy Kyryachenko  1 , Peggy Janich  2 , Salvador A Benitah  2   3   4 , Giovanna Marazzi  1 , David Sassoon  1
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Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle

Vanessa Besson et al. Stem Cells. 2017 Apr.

Abstract

Pw1/Peg3 is a parentally imprinted gene expressed in adult stem cells in every tissue thus far examined including the stem cells of the hair follicle. Using a Pw1/Peg3 reporter mouse, we carried out a detailed dissection of the stem cells in the bulge, which is a major stem cell compartment of the hair follicle in mammalian skin. We observed that PW1/Peg3 expression initiates upon placode formation during fetal development, coincident with the establishment of the bulge stem cells. In the adult, we observed that PW1/Peg3 expression is found in both CD34+ and CD34- populations of bulge stem cells. We demonstrate that both populations can give rise to new hair follicles, reconstitute their niche, and self-renew. These results demonstrate that PW1/Peg3 is a reliable marker of the full population of follicle stem cells and reveal a novel CD34- bulge stem-cell population. Stem Cells 2017;35:1015-1027.

Keywords: Bulge stem cells; Cell cycle; Pw1/Peg3.

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