Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jan 3;18(1):91-95.
doi: 10.1002/cbic.201600560. Epub 2016 Dec 16.

Tetrazine-Responsive Self-immolative Linkers

Kevin Neumann  1 , Sarthak Jain  1 , Alessia Gambardella  1 , Sarah E Walker  1 , Elsa Valero  1 , Annamaria Lilienkampf  1 , Mark Bradley  1
Affiliations

Tetrazine-Responsive Self-immolative Linkers

Kevin Neumann et al. Chembiochem. .

Abstract

Molecules that undergo activation or modulation following the addition of benign external small-molecule chemical stimuli have numerous applications. Here, we report the highly efficient "decaging" of a variety of moieties by activation of a "self-immolative" linker, by application of water-soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.

Keywords: Diels-Alder reaction; doxorubicin; nanoparticles; prodrugs; tetrazine.

PubMed Disclaimer

LinkOut - more resources