Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Dec;40(8):549-555.
doi: 10.1053/j.semperi.2016.09.007. Epub 2016 Nov 15.

Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE)

Girija Natarajan  1 , Athina Pappas  1 , Seetha Shankaran  2
Affiliations
Review

Outcomes in childhood following therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy (HIE)

Girija Natarajan et al. Semin Perinatol. 2016 Dec.

Abstract

In this article, we review the childhood outcomes of neonates with birth depression and/or hypoxic-ischemic encephalopathy. The outcomes of these children prior to the era of hypothermia for neuroprotection will first be summarized, followed by discussion of results from randomized controlled trials of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. The predictors of outcome in childhood following neonatal HIE using clinical and imaging biomarkers following hypothermia therapy will be described.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Shankaran S, Woldt E, Koepke T, Bedard MP, Nandayal R. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev. 1991;25:135–48. - PubMed
    1. Robertson CMT. Long term follow-up of term infants with perinatal asphyxia. In: Stevenson Benitz and Sunshine, editor. Fetal and Neonatal Brain Injury. 3rd. Cambridge University; 2003. pp. 829–858.
    1. Marlow N, Rose AS, Rands CE, Draper ES. Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2005;90:F380–7. - PMC - PubMed
    1. Barnett A, Mercuri E, Rutherford M, et al. Neurological and perceptual-motor outcome at 5 – 6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI. Neuropediatrics. 2002;33:242–8. - PubMed
    1. Odd DE, Whitelaw A, Gunnell D, Lewis G. The association between birth condition and neuropsychological functioning and educational attainment at school age: a cohort study. Arch Dis Child. 2011;96:30–7. - PMC - PubMed

MeSH terms