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. 2016 Oct-Dec;38(4):285-290.
doi: 10.1016/j.bjhh.2016.08.002. Epub 2016 Sep 21.

Survival and treatment response in adults with acute promyelocytic leukemia treated with a modified International Consortium on Acute Promyelocytic Leukemia protocol

Erick Crespo-Solis  1 , Jorge Contreras-Cisneros  2 , Roberta Demichelis-Gómez  2 , Adriana Rosas-López  2 , Juan Mauricio Vera-Zertuche  2 , Alvaro Aguayo  2 , Xavier López-Karpovitch  2
Affiliations

Survival and treatment response in adults with acute promyelocytic leukemia treated with a modified International Consortium on Acute Promyelocytic Leukemia protocol

Erick Crespo-Solis et al. Rev Bras Hematol Hemoter. 2016 Oct-Dec.

Abstract

Acute promyelocytic leukemia has good prognosis in view of the high complete remission and survival rates achieved with therapies containing all-trans retinoic acid or arsenic trioxide. However, there is a significant risk of death during induction due to hemorrhage secondary to disseminated intravascular coagulation. This has contributed to a gap in the prognosis of patients between developed and developing countries. The International Consortium on Acute Promyelocytic Leukemia was created in 2005 and proposed a treatment protocol based on daunorubicin and all-trans retinoic acid stratified by risk geared toward developing countries. Herein are presented the results from the first patient cohort treated in a single developing country hospital employing a slightly modified version of the International Consortium protocol in a real life setting. Twenty patients with acute promyelocytic leukemia were enrolled: 27.8% had low-risk, 55.6% intermediate risk and 16.7% high-risk. The complete remission rate was 94.4% after a median of 42 days. Both relapse rates and death rates were one patient (5.5%) each. No deaths were observed during consolidation. After a median follow-up of 29 months, the overall survival rate was 89.1%. Efficacy and safety of the International Consortium on Acute Promyelocytic Leukemia protocol has been reproduced in acute promyelocytic leukemia patients from a developing country.

Keywords: Acute promyelocytic leukemia; Developing countries; IC-APL protocol; Survival.

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Figures

Figure 1
Figure 1
Induction, consolidation and maintenance regimens.
Figure 2
Figure 2
Study design.
Figure 3
Figure 3
Overall survival.
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References

    1. Arber D.A., Brunning R.D., Le Beau M.M., Falini B. Acute myeloid leukemia and related precursor neoplasms. In: Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., Thiele J., Vardiman J.W., editors. 4th ed. vol. 110. 2008. (WHO classification of tumours of haematopoietic and lymphoid tissues). [Chapter 6]
    1. Hillestad L.K. Acute promyelocytic leukemia. Acta Med Scand. 1957;159:189–194. - PubMed
    1. Lo-Coco F., Ammatuna E., Montesinos P., Sanz M.A. Acute promyelocytic leukemia: recent advances in diagnosis and management. Semin Oncol. 2008;35:401–409. - PubMed
    1. Mejia-Arangure J.M., Bonilla M., Lorenzana R., Juárez-Ocaña S., de Reyes G., Pérez-Saldivar M.L. Incidence of leukemias in children from El Salvador and Mexico City between 1996 and 2000: population-based data. BMC Cancer. 2005;5:33. - PMC - PubMed
    1. Guzmán-Uribe P., Rosas-López A., Zepeda-León J., Crespo-Solís E. Incidence of thrombosis in adults with acute leukemia: a single center experience in Mexico. Rev Inv Clin. 2013;65:130–140. - PubMed

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