Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

Celso Arrais Rodrigues¹, Matheus Vescovi Gonçalves², Maura Rosane Valério Ikoma³, Irene Lorand-Metze⁴, André Domingues Pereira⁵, Danielle Leão Cordeiro de Farias⁶, Maria de Lourdes Lopes Ferrari Chauffaille², Rony Schaffel⁷, Eduardo Flávio Oliveira Ribeiro⁸, Talita Silveira da Rocha⁹, Valeria Buccheri¹⁰, Yuri Vasconcelos¹¹, Vera Lúcia de Piratininga Figueiredo¹², Carlos Sérgio Chiattone¹³, Mihoko Yamamoto¹⁴; Brazilian Group of Chronic Lymphocytic Leukemia.

Affiliations

¹ Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Hospital Sírio Libanês, São Paulo, SP, Brazil. Electronic address: celsoarrais@gmail.com.
² Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Fleury Medicina e Saúde, São Paulo, SP, Brazil.
³ Hospital Amaral Carvalho, Jaú, SP, Brazil.
⁴ Universidade Estadual de Campinas (UNICAMP), São Paulo, SP, Brazil.
⁵ Hospital Sírio Libanês, São Paulo, SP, Brazil.
⁶ Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
⁷ Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
⁸ Hospital Santa Lúcia, Brasília, DF, Brazil.
⁹ A.C Camargo Cancer Center, São Paulo, SP, Brazil; Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
¹⁰ Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brazil.
¹¹ Instituto Goiano de Oncologia e Hematologia (INGOH), Goiânia, GO, Brazil.
¹² Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil.
¹³ Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil; Hospital Samaritano, São Paulo, SP, Brazil.
¹⁴ Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

PMID: 27863764
PMCID: PMC5119662
DOI: 10.1016/j.bjhh.2016.07.004

Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

Celso Arrais Rodrigues et al. Rev Bras Hematol Hemoter. 2016 Oct-Dec.

. 2016 Oct-Dec;38(4):346-357.

doi: 10.1016/j.bjhh.2016.07.004. Epub 2016 Aug 20.

Authors

Affiliations

¹ Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Hospital Sírio Libanês, São Paulo, SP, Brazil. Electronic address: celsoarrais@gmail.com.
² Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; Fleury Medicina e Saúde, São Paulo, SP, Brazil.
³ Hospital Amaral Carvalho, Jaú, SP, Brazil.
⁴ Universidade Estadual de Campinas (UNICAMP), São Paulo, SP, Brazil.
⁵ Hospital Sírio Libanês, São Paulo, SP, Brazil.
⁶ Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.
⁷ Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
⁸ Hospital Santa Lúcia, Brasília, DF, Brazil.
⁹ A.C Camargo Cancer Center, São Paulo, SP, Brazil; Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
¹⁰ Instituto do Câncer do Estado de São Paulo (ICESP), São Paulo, SP, Brazil.
¹¹ Instituto Goiano de Oncologia e Hematologia (INGOH), Goiânia, GO, Brazil.
¹² Instituto de Assistência Médica ao Servidor Público Estadual (IAMSPE), São Paulo, SP, Brazil.
¹³ Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil; Hospital Samaritano, São Paulo, SP, Brazil.
¹⁴ Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

PMID: 27863764
PMCID: PMC5119662
DOI: 10.1016/j.bjhh.2016.07.004

Erratum in

Erratum to "Diagnosis and treatment of chronic lymphocytic leukemia: Recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia" [Rev Bras Hematol Hemoter. 2016;38(4):346-357].
Rodrigues CA, Gonçalves MV, Ikoma MR, Lorand-Metze I, Pereira AD, Farias DL, Chauffaille ML, Schaffel R, Ribeiro EF, Rocha TS, Buccheri V, Vasconcelos Y, Figueiredo VL, Chiattone CS, Yamamoto M; Brazilian Group of Chronic Lymphocytic Leukemia. Rodrigues CA, et al. Rev Bras Hematol Hemoter. 2017 Jan-Mar;39(1):93-94. doi: 10.1016/j.bjhh.2017.01.002. Rev Bras Hematol Hemoter. 2017. PMID: 28270360 Free PMC article. No abstract available.

Abstract

Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19⁺, CD5⁺ and CD23⁺. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In this update, we present the recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia for the diagnosis and treatment of chronic lymphocytic leukemia. The following recommendations are based on an extensive literature review with the aim of contributing to more uniform patient care in Brazil and possibly in other countries with a similar social-economic profile.

Keywords: Chronic lymphocytic leukemia; Cytogenetics; Immunophenotyping; Prognosis; Staging.

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Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

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Diagnosis and treatment of chronic lymphocytic leukemia: recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia

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