In vitro effects of a human monoclonal antibody against the N-methyl-d-aspartate receptor

Josep Dalmau^{1

2}

Affiliations

¹ ICREA-IDIBAPS, Service of Neurology, Hospital Clinic, University of Barcelona, Spain Jdalmau@clinic.ub.es.
² Department of Neurology University of Pennsylvania, Philadelphia, PA, USA.

Comment

Josep Dalmau. Brain. 2017 Feb.

. 2017 Feb;140(2):e9.

doi: 10.1093/brain/aww289. Epub 2016 Nov 17.

Josep Dalmau^{1

2}

¹ ICREA-IDIBAPS, Service of Neurology, Hospital Clinic, University of Barcelona, Spain Jdalmau@clinic.ub.es.
² Department of Neurology University of Pennsylvania, Philadelphia, PA, USA.

No abstract available

Comment in

Reply: In vitro effects of a human monoclonal antibody against the N-methyl-d-aspartate receptor.
Kreye J, Wenke NK, Garner CC, Wardemann H, Prüss H. Kreye J, et al. Brain. 2017 Feb;140(2):e10. doi: 10.1093/brain/aww290. Epub 2016 Nov 17. Brain. 2017. PMID: 27864269 No abstract available.

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.
Kreye J, Wenke NK, Chayka M, Leubner J, Murugan R, Maier N, Jurek B, Ly LT, Brandl D, Rost BR, Stumpf A, Schulz P, Radbruch H, Hauser AE, Pache F, Meisel A, Harms L, Paul F, Dirnagl U, Garner C, Schmitz D, Wardemann H, Prüss H. Kreye J, et al. Brain. 2016 Oct;139(Pt 10):2641-2652. doi: 10.1093/brain/aww208. Epub 2016 Aug 20. Brain. 2016. PMID: 27543972

1. Armangue T, Leypoldt F, Malaga I, Raspall-Chaure M, Marti I, Nichter C, et al. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 2014; 75: 317–23. - PMC - PubMed
1. Armangue T, Moris G, Cantarin-Extremera V, Conde CE, Rostasy K, Erro ME, et al. Autoimmune post-herpes simplex encephalitis of adults and teenagers. Neurology 2015; 85: 1736–43. - PMC - PubMed
1. Castillo-Gomez E, Oliveira B, Tapken D, Bertrand S, Klein-Schmidt C, Pan H, et al. All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class. Mol Psychiatry 2016, in press. doi:10.1038/mp.2016.125. - PubMed
1. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008; 7: 1091–8. - PMC - PubMed
1. DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 2001; 7: 1189–93. - PubMed