Rhinophototherapy in persistent allergic rhinitis

Abstract

Previous published results have revealed that Rhinolight^® intranasal phototherapy is safe and effective in intermittent allergic rhinitis. The present objective was to assess whether phototherapy is also safe and effective in persistent allergic rhinitis. Thirty-four patients with persistent allergic rhinitis were randomized into two groups; twenty-five subjects completed the study. The Rhinolight^® group was treated with a combination of UV-B, UV-A, and high-intensity visible light, while the placebo group received low-intensity visible white light intranasal phototherapy on a total of 13 occasions in 6 weeks. The assessment was based on the diary of symptoms, nasal inspiratory peak flow, quantitative smell threshold, mucociliary transport function, and ICAM-1 expression of the epithelial cells. All nasal symptom scores and nasal inspiratory peak flow measurements improved significantly in the Rhinolight^® group relative to the placebo group and this finding persisted after 4 weeks of follow-up. The smell and mucociliary functions did not change significantly in either group. The number of ICAM-1 positive cells decreased non-significantly in the Rhinolight^® group. No severe side-effects were reported during the treatment period. These results suggest that Rhinolight^® treatment is safe and effective in persistent allergic rhinitis.

Keywords: Intercellular adhesion molecule-1 expression; Intranasal phototherapy; Mucociliary clearance; Nasal inspiratory peak flow; Persistent allergic rhinitis; Rhinolight®.