Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Mar;11(2):177-181.
doi: 10.1111/irv.12436. Epub 2016 Dec 20.

Estimating vaccine effectiveness in preventing laboratory-confirmed influenza in outpatient settings in South Africa, 2015

Johanna M McAnerney  1 , Sibongile Walaza  1 , Stefano Tempia  1   2   3 , Lucille Blumberg  1 , Florette K Treurnicht  1 , Shabir A Madhi  1   4 , Ziyaad Valley-Omar  1   5 , Cheryl Cohen  1
Affiliations

Estimating vaccine effectiveness in preventing laboratory-confirmed influenza in outpatient settings in South Africa, 2015

Johanna M McAnerney et al. Influenza Other Respir Viruses. 2017 Mar.

Abstract

Trivalent seasonal influenza vaccine effectiveness during the 2015 season in South Africa was assessed using a test-negative case control study design. Influenza A(H1N1)pdm09 was the dominant circulating strain. Overall influenza vaccine coverage was 3.2% (29/899). The vaccine effectiveness estimate, against any influenza virus infection, adjusted for age, underlying conditions and timing within season was 46.2% (95% CI: -23.5 to 76.5), and 53.6% (95% CI: -62.6 to 80.3) against influenza A(H1N1)pdm09.

Keywords: effectiveness; influenza; vaccine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Flow of specimens and allocation of cases and controls for VE analysis, South Africa 2015
Figure 2
Figure 2
Test‐negative controls and laboratory‐confirmed cases by week and virus subtype: Viral Watch programme, South Africa, 4 May‐13 September 2015 [Colour figure can be viewed at wileyonlinelibrary.com]
See this image and copyright information in PMC

References

    1. McAnerney JM, Cohen C, Moyes J, et al. Twenty‐five years of outpatient influenza surveillance in South Africa, 1984‐2008. J Infect Dis. 2012;206(Suppl 1):S153–S158. - PubMed
    1. Ntshoe GM, McAnerney JM, Tempia S, et al. Influenza epidemiology and vaccine effectiveness among patients with influenza‐like illness, viral watch sentinel sites, South Africa, 2005‐2009. PLoS One. 2014;9:e94681. - PMC - PubMed
    1. McAnerney JM, Walaza S, Cohen AL, et al. Effectiveness and knowledge, attitudes and practices of seasonal influenza vaccine in primary healthcare settings in South Africa, 2010‐2013. Influenza Other Respir Viruses. 2015;9:143–150. - PMC - PubMed
    1. McAnerney JM, Treurnicht F, Walaza S, et al. Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014. Influenza Other Respir Viruses. 2015;9:209–215. - PMC - PubMed
    1. Walaza S, Cohen C. Recommendations pertaining to the use of influenza vaccines and influenza antiviral drugs: Influenza 2015. SAMJ. 2015;105:90–91. - PubMed

MeSH terms

Substances

LinkOut - more resources