Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Oct;8(10):E1420-E1422.
doi: 10.21037/jtd.2016.10.03.

Commentary on "Randomized trial of thymectomy in myasthenia gravis"

Affiliations
Comment

Commentary on "Randomized trial of thymectomy in myasthenia gravis"

Alexandar Tzankov. J Thorac Dis. 2016 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Typical appearance of lymphofollicular thymic hyperplasia in an early onset myasthenia gravis patient. Note a large germinal center (middle of the photography) as well as a Hassall’s body (left lower corner). These germinal centers contain antigenically selected and somatically hypermutated anti-acetylcholine receptor-specific B-cells, thus representing one of the earlier “fountains of evil” in myasthenia gravis.

Comment in

  • Randomized trial of thymectomy in myasthenia gravis.
    Wolfe GI, Kaminski HJ, Sonnett JR, Aban IB, Kuo HC, Cutter GR. Wolfe GI, et al. J Thorac Dis. 2016 Dec;8(12):E1782-E1783. doi: 10.21037/jtd.2016.12.80. J Thorac Dis. 2016. PMID: 28149641 Free PMC article. No abstract available.

Comment on

  • Randomized Trial of Thymectomy in Myasthenia Gravis.
    Wolfe GI, Kaminski HJ, Aban IB, Minisman G, Kuo HC, Marx A, Ströbel P, Mazia C, Oger J, Cea JG, Heckmann JM, Evoli A, Nix W, Ciafaloni E, Antonini G, Witoonpanich R, King JO, Beydoun SR, Chalk CH, Barboi AC, Amato AA, Shaibani AI, Katirji B, Lecky BR, Buckley C, Vincent A, Dias-Tosta E, Yoshikawa H, Waddington-Cruz M, Pulley MT, Rivner MH, Kostera-Pruszczyk A, Pascuzzi RM, Jackson CE, Garcia Ramos GS, Verschuuren JJ, Massey JM, Kissel JT, Werneck LC, Benatar M, Barohn RJ, Tandan R, Mozaffar T, Conwit R, Odenkirchen J, Sonett JR, Jaretzki A 3rd, Newsom-Davis J, Cutter GR; MGTX Study Group. Wolfe GI, et al. N Engl J Med. 2016 Aug 11;375(6):511-22. doi: 10.1056/NEJMoa1602489. N Engl J Med. 2016. PMID: 27509100 Free PMC article. Clinical Trial.

References

    1. Weigert C. Pathologisch-anatomischer Beitrag zur Erb’schen Krankheit (Myasthenia gravis). Neurologisches Centralblatt 1901;20:597-601.
    1. Hughes T. The early history of myasthenia gravis. Neuromuscul Disord 2005;15:878-86. 10.1016/j.nmd.2005.08.007 - DOI - PubMed
    1. Vincent A. Unravelling the pathogenesis of myasthenia gravis. Nat Rev Immunol 2002;2:797-804. 10.1038/nri916 - DOI - PubMed
    1. Melzer N, Ruck T, Fuhr P, et al. Clinical features, pathogenesis, and treatment of myasthenia gravis: a supplement to the Guidelines of the German Neurological Society. J Neurol 2016;263:1473-94. 10.1007/s00415-016-8045-z - DOI - PMC - PubMed
    1. Buckley C, Newsom-Davis J, Willcox N, et al. Do titin and cytokine antibodies in MG patients predict thymoma or thymoma recurrence? Neurology 2001;57:1579-82. 10.1212/WNL.57.9.1579 - DOI - PubMed

LinkOut - more resources