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. 2016 Nov-Dec;20(6):752-755.
doi: 10.4103/2230-8210.192909.

Serum adiponectin levels in gestational diabetes mellitus

Abhijit Bhograj  1 , K M Suryanarayana  1 , Ashwini Nayak  2 , N S Murthy  3 , Mala Dharmalingam  1 , Pramila Kalra  1
Affiliations

Serum adiponectin levels in gestational diabetes mellitus

Abhijit Bhograj et al. Indian J Endocrinol Metab. 2016 Nov-Dec.

Abstract

Introduction: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy.[1] Pregnancy is a unique situation in which there is a physiological temporary increase in insulin resistance (IR). The mechanisms responsible for the gestational-induced IR are not completely understood. The current study was undertaken to compare adiponectin levels during 24-28 weeks period of gestation in drug-naive newly diagnosed GDM women with a cohort of normoglycemic pregnant women.

Subjects and methods: A total of 47 pregnant women in the age group of 18-40 years were included in this cross-sectional study, of which 13 were GDM cases and 34 were normoglycemic controls. Serum adiponectin level was analyzed by enzyme-linked immunosorbent assay.

Results: The mean adiponectin level was 16.92 ng/ml (standard deviation [SD] = 2.78) and 19.38 ng/ml (SD = 2.71) in case and control groups, respectively, and the difference was found to be statistically significant (P = 0.008).

Conclusion: Our study demonstrated decreased serum adiponectin levels in women with GDM when compared with age- and body mass index-matched euglycemic pregnant women.

Keywords: Adiponectin; antenatal screening; gestational diabetes mellitus.

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