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Editorial
. 2016 Oct;4(Suppl 1):S18.
doi: 10.21037/atm.2016.10.23.

The role of glutamate transport and SLC7A11 expression in tumor-associate seizures and survival in patients with malignant gliomas

Joseph R Keen  1 , Sharon A Swanger  2 , Stephen F Traynelis  2 , Jeffrey J Olson  1
Affiliations
Editorial

The role of glutamate transport and SLC7A11 expression in tumor-associate seizures and survival in patients with malignant gliomas

Joseph R Keen et al. Ann Transl Med. 2016 Oct.
No abstract available

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Conflict of interest statement

J. J. Olson is a consultant for the American Cancer Society. S. F. Traynelis is cofounder of NeurOp Inc., the Primary Investigator on a research grant to Emory University from Janssen, and a paid consultant for NeurOp, Pfizer, and J. R. Keen and S. A. Swanger have no conflicts of interest to declare.

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References

    1. Alifieris C, Trafalis DT. Glioblastoma multiforme: Pathogenesis and treatment. Pharmacol Ther 2015;152:63-82. 10.1016/j.pharmthera.2015.05.005 - DOI - PubMed
    1. Wilson TA, Karajannis MA, Harter DH. Glioblastoma multiforme: State of the art and future therapeutics. Surg Neurol Int 2014;5:64. 10.4103/2152-7806.132138 - DOI - PMC - PubMed
    1. Buckingham SC, Campbell SL, Haas BR, et al. Glutamate release by primary brain tumors induces epileptic activity. Nat Med 2011;17:1269-74. 10.1038/nm.2453 - DOI - PMC - PubMed
    1. Robert SM, Buckingham SC, Campbell SL, et al. SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma. Sci Transl Med 2015;7:289ra86. 10.1126/scitranslmed.aaa8103 - DOI - PMC - PubMed
    1. Buckingham SC, Robel S. Glutamate and tumor-associated epilepsy: glial cell dysfunction in the peritumoral environment. Neurochem Int 2013;63:696-701. 10.1016/j.neuint.2013.01.027 - DOI - PMC - PubMed

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