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Editorial
. 2016 Nov 7:3:75.
doi: 10.21037/sci.2016.09.17. eCollection 2016.

TGF-β: a master regulator of the bone marrow failure puzzle in Fanconi anemia

Paula Río  1 , Juan A Bueren  1
Affiliations
Editorial

TGF-β: a master regulator of the bone marrow failure puzzle in Fanconi anemia

Paula Río et al. Stem Cell Investig. .
No abstract available

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Conflict of interest statement

The Division of Hematopoietic Innovative Therapies receives funding from Rocket Pharma.

Figures

Figure 1
Figure 1
The multicomponent puzzle of bone marrow failure (BMF) in Fanconi anemia (FA). The presence of a hyperactive TGF-β pathway constitutes a novel and key piece to explain the BMF feature of FA. Other important components of this puzzle, including oxidative damage, inflammatory cytokines, increased apoptosis, cytokinesis defects, endogenous interstrand crosslinking agents (acetaldehydes) and physiological stress have already been described. Future studies would help to unravel the existence of novel and essential components of the intriguing puzzle of FA-associated BMF.
See this image and copyright information in PMC

Comment on

References

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