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Review
. 2016:2016:4986797.
doi: 10.1155/2016/4986797. Epub 2016 Oct 27.

The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation

Chao Zhang  1 , Shuo Wang  1 , Cheng Yang  2 , Ruiming Rong  3
Affiliations
Review

The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation

Chao Zhang et al. J Immunol Res. 2016.

Abstract

Myeloid derived suppressor cells (MDSCs) are a heterogeneous population of myeloid precursor and progenitor cells and endowed with a robust immunosuppressive activity in multiple pathophysiological conditions. Recent studies have uncovered the crosstalk between MDSCs and immune cells (i.e., natural killer cells, dendritic cells, macrophages, natural killer T cells, and regulatory T cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. Considering their strong immunosuppressive capability, MDSCs could become a prospective clinical regimen during transplantation tolerance induction, resulting in long-term graft survival with decreased or without immunosuppressive drugs. The review summarized recent research advances in this field and looked ahead at the research directions in the future.

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Figures

Figure 1
Figure 1
The role of MDSCs in immune tolerance induction of transplant. The crosstalk between MDSCs and immune cells such as NK cells, DCs, Tregs, macrophages, and NKT cells contributes to the establishment of immune tolerance in kidney transplant, skin transplant, pancreatic islet transplant, cardiac transplant, and GVHD in HSC transplant (NK cells: natural killer cells; DCs: dendritic cells; Tregs: regulatory T cells; NKT cells: natural killer T cells; GVHD: graft-versus-host disease; HSC: hematopoietic stem cell).
See this image and copyright information in PMC

References

    1. Serafini P., Borrello I., Bronte V. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Seminars in Cancer Biology. 2006;16(1):53–65. doi: 10.1016/j.semcancer.2005.07.005. - DOI - PubMed
    1. Gabrilovich D. I., Bronte V., Chen S.-H., et al. The terminology issue for myeloid-derived suppressor cells. Cancer Research. 2007;67(1):425–426. doi: 10.1158/0008-5472.can-06-3037. - DOI - PMC - PubMed
    1. Youn J.-I., Nagaraj S., Collazo M., Gabrilovich D. I. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. Journal of Immunology. 2008;181(8):5791–5802. doi: 10.4049/jimmunol.181.8.5791. - DOI - PMC - PubMed
    1. Bartmann C., Junker M., Segerer S. E., Hausler S. F., Krockenberger M., Kammerer U. CD33(+) /HLA-DR(neg) and CD33(+) /HLA-DR(+/-) cells: rare populations in the human decidua with characteristics of MDSC. American Journal of Reproductive Immunology. 2016;75(5):539–556. doi: 10.1111/aji.12492. - DOI - PubMed
    1. Nagaraj S., Gupta K., Pisarev V., et al. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nature Medicine. 2007;13(7):828–835. doi: 10.1038/nm1609. - DOI - PMC - PubMed

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