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. 1989 Jul;38(7):942-5.
doi: 10.2337/diab.38.7.942.

Primary association of HLA-DQw8 with type I diabetes in DR4 patients

D Owerbach  1 , S Gunn, K H Gabbay
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Primary association of HLA-DQw8 with type I diabetes in DR4 patients

D Owerbach et al. Diabetes. 1989 Jul.

Abstract

DNA from 164 Caucasian type I (insulin-dependent) diabetic patients and 200 Caucasian nondiabetic control blood donors were analyzed by the polymerase chain reaction technique for HLA-DR4 and the associated Dw and DQB subtypes of DR4. The DQw8 subtype of HLA-DR4 was associated with type I diabetes in all DR4 subgroups (DR4/3 and DR4/non-3). Dw subtypes of DR4 other than DW10 did not confer additional association with type I diabetes. Thus, the DQ region appears to provide the primary major histocompatibility association with type I diabetes in most DR4 patients.

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