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Randomized Controlled Trial
. 2016 Nov 22;16(1):63.
doi: 10.1186/s12880-016-0166-4.

Comparison of coronary arterial lumen dimensions on angiography and plaque characteristics on optical coherence tomography images and their changes induced by statin

Nana Dong  1   2 , Zulong Xie  1 , Wei Wang  1 , Jiannan Dai  1 , Meng Sun  2 , Zhongyue Pu  1 , Jinwei Tian  3 , Bo Yu  4   5
Affiliations
Randomized Controlled Trial

Comparison of coronary arterial lumen dimensions on angiography and plaque characteristics on optical coherence tomography images and their changes induced by statin

Nana Dong et al. BMC Med Imaging. .

Abstract

Background: Coronary angiography (CAG) is widely used to assess lumen dimensions, and optical coherence tomography (OCT) is used to evaluate the characteristics of atherosclerotic plaque. This study was aimed to compare coronary lumen dimensions using CAG and plaque characteristics using OCT and their changes during statin therapy.

Methods: We identified 97 lipid-rich plaques from 69 statin-naïve patients, who received statin therapy in the following 12 months. CAG and OCT examinations were conducted at baseline and 12-month follow-up period.

Results: Lesion length, as measured by CAG, was closely correlated with lipid length by OCT (baseline: r = 0.754, p < 0.001; follow-up: r = 0.639, p < 0.001). However, no significant correlations were found between the other findings on OCT and data on CAG. With 12-month statin therapy, microstructures of lipid-rich plaques were significantly improved, but CAG-derived lumen dimensions were not improved. Moreover, we found no significant relationship between changes in OCT measurements and changes in CAG data over time.

Conclusion: Lipid length on OCT and lesion length on CAG were closely correlated. However, plaque microstructural characteristics on OCT showed no significantly statistically correlations with lumen dimensions on CAG, neither did their evolutionary changes induced by statin over time.

A retrospectively registered study: Clinical trial registry: ClinicalTrial.gov. Registered number: NCT01023607 . Registered 1 December 2009.

Keywords: Atherosclerosis; Coronary angiography; Optical coherence tomography; Statin.

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Figures

Fig. 1
Fig. 1
Comparisons of minimal lumen diameter in terms of OCT-derived plaque type. According to OCT-derived plaque types, plaques were classified into TCFAs and ThCFAs, with or without macrophage, or microvessels, or cholesterol crystals. Minimal lumen diameter showed no significant differences between groups
Fig. 2
Fig. 2
Comparisons of diameter stenosis in terms of OCT-derived plaque type. At baseline, diameter stenosis were significantly worse in TCFAs (p = 0.021). To compare the data at baseline and at follow-up in ThCFAs, we found that diameter stenosis was growing worse at follow-up (p = 0.014)
See this image and copyright information in PMC

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