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. 2016 Oct;19(10):1144-1150.

The effect of Quercus brantii gall extract on burn wound healing in rat

Faraidoon Haghdoost  1 , Mohammad Mehdi Baradaran Mahdavi  2 , Behzad Zolfaghari  3 , Mohammad Hossein Sanei  4 , Somaye Najafi  5 , Alireza Zandifar  1 , Navid Manouchehri  2 , Shaghayegh Haghjooy Javanmard  5
Affiliations

The effect of Quercus brantii gall extract on burn wound healing in rat

Faraidoon Haghdoost et al. Iran J Basic Med Sci. 2016 Oct.

Abstract

Objectives: The aim of the present study was to evaluate the effect of Quercus brantii galls extract on the rat skin burn wound healing.

Materials and methods: Ethanol extract of the galls of Q. brantii was used to treat the induced burn wounds on the back of 32 Wistar rats divided into 4 groups. The groups were treated by placebo, 1%, 2% and 4% concentration gall extract gels for 14 days and the efficacy of treatment was assessed based on reduction of burn wound area, as well as histological and molecular characteristics.

Results: The mean wound surface in the 14th day, in all groups treated by Q. brantii gall extracts were larger than control group and the differences were statistically significant (P=0.043). The mean histological wound healing scores were not statistically different. Analysis of nitric oxide and platelet derived growth factor concentration in wound fluids in the 5th day of study showed that there was not any significant difference between groups (P=0.468 and 0.312 respectively). Fibroblast growth factor (bFGF) concentration in the wound fluids, was significantly higher in group treated with 1% gall extract gel in comparison to the control group (P=0.026).

Conclusion: Our results could not prove the significant positive effect of Q. brantii galls extract on the burning wound healing. More studies with more groups treated with different doses of the Q. brantii extract are recommended.

Keywords: Burn wound healing; Gall extract; Quercus Brantii.

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Figures

Figure 1
Figure 1
Macroscopic morphology of skin burn wound in the first day of the study created by 10-sec application of 1.5 * 1.5 aluminum plaque which was heated to 100 degree centigrade (a). Macroscopic morphology of the wounds after 14-day treatment by Quercus Brantii gall extract (b). G1: control group/ G2: Group treated with 1% concentration extract/ G3: Group treated with 2% concentration extract/ G4: Group treated with 4% concentration extract
Figure 2
Figure 2
Histopathology of burn wounds at 14th day of the study. Stained with H&E (200x). G1: control group/ G2: Group treated with 1% concentration gall extract/ G3: Group treated with 2% concentration gall extract/ G4: Group treated with 4% concentration gall extract/ Asterisks show capillaries. Small arrows show fibroblasts. Long arrows show granulation
See this image and copyright information in PMC

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References

    1. Stander M, Wallis LA. The emergency management and treatment of severe burns. Emerg Med Int 2011. 2011:161375. - PMC - PubMed
    1. Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007;33:139–148. - PubMed
    1. Bastos ML, Houly RL, Conserva LM, Andrade VS, Rocha EM, Lyra Lemos RP. Antimicrobial and wound healing activities of Piper hayneanum. J Chem Pharm Res. 2011;3:213–222.
    1. Singer AJ, Clark R. Cutaneous wound healing. N Engl J Med. 1999;341:738–746. - PubMed
    1. Cohen JL, Jorizzo JL, Kircik LH. Use of a topical emulsion for wound healing. J Support Oncol. 2007;5:1–9. - PubMed

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