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. 2014 Jun;2(2):77-81.
doi: 10.1016/j.jgar.2014.01.002. Epub 2014 Feb 4.

First report of a clinical isolate of Leclercia adecarboxylata harbouring multiple resistance genes in Uruguay and review of the literature

Virginia García-Fulgueiras  1 , Verónica Seija  2 , Paula Aguerrebere  1 , Nicolás F Cordeiro  1 , Rafael Vignoli  3
Affiliations

First report of a clinical isolate of Leclercia adecarboxylata harbouring multiple resistance genes in Uruguay and review of the literature

Virginia García-Fulgueiras et al. J Glob Antimicrob Resist. 2014 Jun.

Abstract

Here we report the detection of a Leclercia adecarboxylata strain, isolated from a case of osteomyelitis, harbouring multiple antibiotic resistance genes encoded on a 450-kb IncHI1/HI2 conjugative plasmid (pLa12). The plasmid carried a complex class 1 integron with the genetic array intI1-aac(6')-Ib-cr-blaOXA-1-catB3-arr3-qacEΔ1-sul1-ISCR1; in addition, a blaDHA-1-like allele linked to ampR-qacEΔ1-sul1 as well as blaSHV-12, blaTEM-1 and qnrB4-like genes were found. To the best of our knowledge, this is the first report of L. adecarboxylata harbouring transferable resistance genes to quinolones, chloramphenicol and rifampicin as well as a plasmidic class C β-lactamase.

Keywords: ESBL; Extended-spectrum β-lactamase; Integron; PMQR; Plasmid-mediated quinolone resistance.

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