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. 2017 Jan 2;12(1):19-26.
doi: 10.1080/15592294.2016.1252891. Epub 2016 Nov 22.

Epigenetic changes as prognostic predictors in endometrial carcinomas

Sanja A Farkas  1 , Bengt G Sorbe  2 , Torbjörn K Nilsson  3
Affiliations

Epigenetic changes as prognostic predictors in endometrial carcinomas

Sanja A Farkas et al. Epigenetics. .

Abstract

Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively). We identified specific DNA methylation signature in high-risk endometrial tumors, and potential molecular biomarker genes (TBX2, CHST11, and NID2) associated with unfavorable clinical predictive and prognostic factors.

Keywords: DNA methylation; FIGO grade; endometrial cancer; prognosis.

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Figures

Figure 1.
Figure 1.
Heat map showing differentially methylated CpG sites with a β ≥ |0.3| in tumors of FIGO-grade 1 (blue) and FIGO-grade 3 (yellow).
Figure 2.
Figure 2.
Cancer-specific survival rate vs. methylation of gene TBX2 (cg07095230). Group 1: hypomethylated (≤ median value) and Group 2: hypermethylated (> median value).
See this image and copyright information in PMC

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