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Comment
. 2016 Nov 21;39(4):392-394.
doi: 10.1016/j.devcel.2016.11.007.

Redox Paradox: Can Hypoxia Heal Ischemic Hearts?

Nuno Guimarães-Camboa  1 , Sylvia M Evans  2
Affiliations
Comment

Redox Paradox: Can Hypoxia Heal Ischemic Hearts?

Nuno Guimarães-Camboa et al. Dev Cell. .

Abstract

Adult cardiomyocytes are largely thought to lack proliferative and therefore regenerative potential. Reporting in Nature, Nakada et al. (2016) find that a hypoxic regime reduces mitochondrial metabolism and promotes proliferation in adult mouse cardiomyocytes, resulting in increased regeneration following myocardial infarction. These findings suggest the potential to transform post-MI care.

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Figures

Figure 1
Figure 1
Graphical Representation of Experimental Design and Summary of Differences between Hypoxic and Control Hearts, Reported by Nakada et al. (A) Wild-type animals. (B) Wild-type animals post-MI. Abbreviations: BrdU, Bromodeoxyuridine; CM, cardiomyocyte; LV, left ventricle; pH3, phospho-histone 3; RV, right ventricle.
See this image and copyright information in PMC

Comment on

  • Hypoxia induces heart regeneration in adult mice.
    Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah AM, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Hu Z, Deberardinis RJ, Schiattarella G, Hill JA, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA. Nakada Y, et al. Nature. 2017 Jan 12;541(7636):222-227. doi: 10.1038/nature20173. Epub 2016 Oct 31. Nature. 2017. PMID: 27798600

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